Partial splenic embolization in a patient with SLE.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1990 English Publisher:Japan Society for Clinical ImmunologyJournal:Japanese Journal of Clinical Immunology, volume 13, pages 165-169 (issn: 0911-4300, eissn: 1349-7413,

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Authors: Kouhei Maehiro; Masahiro Sugawara; Hiroshi Hashimoto; Shunichi Hirose;

doi: 10.2177/jsci.13.165

Partial splenic embolization in a patient with SLE.

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Abstract

γ部分的脾動脈塞栓術(partial splenic embolization; PSE)を施行した著明な血小板減少を伴う全身性エリテマトーデス(SLE)の1例を報告する.患者は30歳女性でplatelet associated IgG (PAIgG)およびLupus anticoagulant (LAC)陽性のSLEでsteroid療法を施行していたが, steroid剤の減量とともに血小板数が著しく減少し, 1.0×4/μl以下となった.このため, betamethasone 50 mg/日3日間のセミパルス療法, γ-globulin大量療法を3回ずつ施行したが一時的な効果しか得られなかった.脾摘術を行うには危険性が高いためPSEを施行した. PSE施行後は, 1年を経ても血小板数は3.0×104/μl～5.0×104/μl程度を維持している. steroid抵抗性の血小板減少を伴った腎機能低下のあるSLEで内科的治療が無効な場合, PSEは比較的侵襲が少なく有効な治療法であると考えられる.

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Juntendo University
Japan

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