Background: Madhumeha has become a burning issue in day today life. The term Prameha has broader connotations indicating the increased quantity and quality of urination. Where as Madhumeha, is the condition where patient passes urine like honey. Madhumeha vis-à-vis Diabetes mellitus is a group of metabolic disorder characterized by Hyperglycaemia resulting from defects in Insulin secretion or its Action. In classics the prime importance has been given to Basti among Panchakarma and even termed as Ardhachikitsa or complete Chikitsa, as it produces multi-dimensional effect. Objectives: To evaluate the efficacy of the Vasti in Trio-vasti pattern and also to evaluate the efficacy of the Avapadravya in Vasti in Madhumeha, Methodology: 30 patients were selected for the study and equally divided in three groups. Group-A: 10 patients received Somavalka Kashaya Niruha Yoga Basti. Group-B: 10 patients received Somavalka Kashaya with Aavapa Dravya Niruha Yoga Basti. Group-C: 10 patients received Somavalka Kashaya Niruha Yoga Basti in Trio-vasti pattern. Results and Conclusion: After proper administration of Somavalka Kashaya Yogabasti in all the groups the results were noted that, it gives immediate and lasting results, both symptomatically and in sugar levels. Among 30 patients, 7 patients (23.33%) showed mild response, 12 Patients (40%) showed moderate response, 11 patients (36.66%) showed marked response. In mild and moderate type of Madhumeha patients, Somavalka Kashaya given in Trio-Basti helps to control it. Along with Bastikarma, administration of Patya Aahara- Vihara and Shamanoushadis may give better effect.