Rise of antibiotic resistant pathogenic bacteria namely Methicillin Resistant Staphylococcus aureus (MRSA) and Multiple drug resistant Escherichia coli (MDR E. coli results in reduced efficacy of currently used antibacterial agents. Medicinal plants serve as potential targets for biologically effective antibacterial agents. The present study determined the phytochemical and invitro antibacterial activity of ethanol, chloroform, hexane and water extracts of whole plant of Andrographis paniculata against MRSA and MDR Escherichia coli. Zone of inhibition diameters were measured. Compared to all the extracts, ethanolic extract showed highest activity. The antibacterial activity was absent in hexane and water extracts. Chloroform extracts showed moderately good activity. The antibacterial compounds found in ethanolic extract were flavanoids, saponins and alkaloids.