Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 2 (mGluR2)

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2005 English Publisher:Bentham Science Publishers Ltd.Journal:Current Topics in Medicinal Chemistry, volume 5, pages 869-884 (issn: 1568-0266,

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Authors: Michael T, Rudd; John A, McCauley;

doi: 10.2174/1568026054750281

pmid: 16178732

Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 2 (mGluR2)

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Abstract

This article describes recent medicinal chemistry progress toward selective potentiators of the metabotropic glutamate receptor 2 (mGluR2). Groups at Lilly and Merck have identified new classes of potentiators that exhibit selectivity for mGluR2 over the seven other subtypes of mGluRs. Structure-activity relationships as well as pharmacokinetic properties and in vivo activity are reviewed.

Related Organizations

Merck & Co.
United States

Keywords

Structure-Activity Relationship, Allosteric Regulation, Drug Design, Excitatory Amino Acid Agonists, Animals, Humans, Receptors, Metabotropic Glutamate

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