The Sodium-Iodide Symporter

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2004 English Publisher:Bentham Science Publishers Ltd.Journal:Current Drug Targets - Immune, Endocrine & Metabolic Disorders, volume 4, pages 167-174 (issn: 1568-0088, eissn: 0000-0000,

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Authors: C H, Baker; J C, Morris;

doi: 10.2174/1568008043339839

pmid: 15379719

The Sodium-Iodide Symporter

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Abstract

The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.

Related Organizations

Mayo Clinic
United States

Keywords

Symporters, Thyroid Gland, Animals, Humans, Thyroid Diseases

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