descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2008 English Publisher:Bentham Science Publishers Ltd.Journal:Current Pharmaceutical Biotechnology, volume 9, pages 239-241 (issn: 1389-2010,

Authors: Philip E. Pummill; Stephen Brown;

doi: 10.2174/138920108785161488

pmid: 18691082

Recombinant Production of Hyaluronic Acid

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Abstract

Presently, the two main commercial sources of hyaluronic acid (HA) are rooster combs and streptococci. Harvesting from rooster combs is complex and costly. Streptococci are difficult to genetically manipulate and require complex media for growth. Both sources have potential problems with unwanted by-products, such as allergens and toxins. These problems can be solved by producing the HA with safe bacilli that are expressing a recombinant HA synthase (HAS).

Related Organizations

Novozymes (Denmark)
Denmark

Keywords

Uridine Diphosphate N-Acetylglucosamine, Fermentation, Uridine Diphosphate Glucuronic Acid, Glucuronosyltransferase, Hyaluronic Acid, Hyaluronan Synthases, Recombinant Proteins, Bacillus subtilis, Biotechnology

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