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Polyethylenimine In Medicinal Chemistry

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2008 Italy Publisher:Bentham Science Publishers Ltd.Journal:Current Medicinal Chemistry, volume 15, pages 2,826-2,839 (issn: 0929-8673,

Authors: VICENNATI, PAOLA; GIULIANO, ANTONELLA; ORTAGGI, Giancarlo; MASOTTI, ANDREA;

doi: 10.2174/092986708786242778

pmid: 18991638

handle: 11573/670450

Polyethylenimine In Medicinal Chemistry

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Abstract

Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.

Country

Italy

Related Organizations

Keywords

Drug Delivery Systems, Polyethylenimine; polymer; DNA; transfection; gene therapy; drug delivery; medicinal chemistry; biomedical applications, Anti-Infective Agents, Coated Materials, Biocompatible, Molecular Structure, Photochemotherapy, Chemistry, Pharmaceutical, Nanoparticles, Polyethyleneimine

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	107
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%