Structure and Function of Bovine Pancreatic Deoxyribonuclease I
Copyright policy )Structure and Function of Bovine Pancreatic Deoxyribonuclease I
Bovine pancreatic deoxyribonuclease I (bpDNase), the first DNase discovered, is the best characterized among various types of DNase. A catalytic mechanism has been suggested based on the X-ray structure of the bpDNase-octamer complex. In this review, we will focus on three aspects: 1) the distinctive functions of the two structural calcium atoms; 2) the biological functions of the two disulfides; and 3) the involvement of the N- and C-terminal fragments in the enzyme folding for activity.
- National Taiwan University of Arts Taiwan
- National Ilan University Taiwan
Models, Molecular, Protein Folding, Molecular Structure, Protein Conformation, Molecular Sequence Data, Crystallography, X-Ray, Structure-Activity Relationship, Mutagenesis, Site-Directed, Animals, Deoxyribonuclease I, Humans, Cattle, Amino Acid Sequence, Disulfides, Sequence Alignment
Models, Molecular, Protein Folding, Molecular Structure, Protein Conformation, Molecular Sequence Data, Crystallography, X-Ray, Structure-Activity Relationship, Mutagenesis, Site-Directed, Animals, Deoxyribonuclease I, Humans, Cattle, Amino Acid Sequence, Disulfides, Sequence Alignment
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