During fiscal year 1999, various programs and projects will require analyses from the 222-S Laboratory. In order to prioritize and successfully meet the analytical demands of all the customers, multiple organizations across the Tank Waste Remediation System (TWRS) must work together. One of the projects that will require analyses from the 222-S Laboratory is the retrieval project. Successful completion of retrieval project objectives requires cooperation among four TWRS organizations. The requirements and expectations regarding retrieval project analytical work were examined in order to define roles and responsibilities for each of these TWRS organizations. This memorandum of understanding (MOU) documents the results of this review and establishes the roles and responsibilities. This MOU is subdivided into three sections, the first of which is this introduction. Section 2 provides a summary of the overall roles and responsibilities with respect to retrieval project analytical work for the four TWRS organizations involved. The final section describes the individual interfaces involved in performing retrieval project analytical work, and discusses the roles and responsibilities with respect to each individual interface.