
doi: 10.2172/6141035
The current objective of our research is to investigate the dose-response relationship of the lethal and mutagenic effects of exposure of cells to radon and its decay products. Dose-rate dependence will be studied, as well as the nature of the DNA lesions. The effect of DNA repair on the lethal and mutagenic effects of exposure and on the character of the DNA lesions will be investigated by comparing the response of L5178Y strains which differ in their ability to rejoin X radiation-induced DNA double-strand breaks. This report discusses progress incurred from 4/1/1988--10/1/1990. 5 refs., 9 figs., 6 tabs.
Daughter Products, Even-Even Nuclei, Cells, Biological Repair, Adducts, Heavy Nuclei, & Tissue Culture, Days Living Radioisotopes, Doses, Rodents, Dna Repair, Radioinduction, Mice, Isotopes, Animal Cells, Thermal, Recovery, Dna Adducts, Vertebrates 560120* -- Radiation Effects On Biochemicals, Radiations, Animals, X Radiation, Radon 222, Strand Breaks, Mortality, Radon Isotopes, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat, Mammals, Radioisotopes, Progress Report, Toxicity, Alpha Decay Radioisotopes, Electromagnetic Radiation, Biological Recovery, Biological Effects, 63 Radiation, Lethal Doses, Cell Cultures, Document Types, Nuclei, Radiation Effects, Dose-Response Relationships, Mutagenesis, Biological Radiation Effects, Counting Techniques, Scintillation Counting, Repair, Ionizing Radiations
Daughter Products, Even-Even Nuclei, Cells, Biological Repair, Adducts, Heavy Nuclei, & Tissue Culture, Days Living Radioisotopes, Doses, Rodents, Dna Repair, Radioinduction, Mice, Isotopes, Animal Cells, Thermal, Recovery, Dna Adducts, Vertebrates 560120* -- Radiation Effects On Biochemicals, Radiations, Animals, X Radiation, Radon 222, Strand Breaks, Mortality, Radon Isotopes, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat, Mammals, Radioisotopes, Progress Report, Toxicity, Alpha Decay Radioisotopes, Electromagnetic Radiation, Biological Recovery, Biological Effects, 63 Radiation, Lethal Doses, Cell Cultures, Document Types, Nuclei, Radiation Effects, Dose-Response Relationships, Mutagenesis, Biological Radiation Effects, Counting Techniques, Scintillation Counting, Repair, Ionizing Radiations
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