Mutagenicity of radon and radon daughters
Mutagenicity of radon and radon daughters
The objective of our research is to investigate the dose-response relationship of the lethal and mutagenic effects of exposure of cells to radon and its decay products. Dose rate dependence and the nature of the DNA lesion will be studied, using the thymidine kinase and HPRT loci to measure mutation frequency. A deficiency in DNA repair is shown to lead to a greater proportion of mutants with intergenic lesions. The cytotoxic effects of radon and its daughters are similar in human TK6 lymphoblasts and mouse L5178Y lymphoblasts, the cell line used in previous experiments. The results of molecular analysis of four spontaneous and 25 X-radiation induced HPRT{sup {minus}} mutants. Eleven radon-induced HPRT{sup {minus}} mutants have been isolated, and will be analyzed in a similar fashion. 9 figs.
- University of North Texas United States
Daughter Products, Primates, Design, Radiation Doses, Doses, Rodents, Radioinduction, Mice, Isotopes, Animal Cells, Thermal, Dosimetry, Radiations, Vertebrates 560160* -- Radionuclide Effects, Animals, X Radiation, Gene Mutations, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat, Mammals, Fluids, Progress Report, Radioisotope Generators, Electromagnetic Radiation, Biological Effects, 63 Radiation, Dose Rates, Elements, Document Types, Rare Gases, Radiation Effects, Kinetics, Nonmetals, Radon, Man, & Toxicology, Biological Radiation Effects, Gases, Mutations, Ionizing Radiations
Daughter Products, Primates, Design, Radiation Doses, Doses, Rodents, Radioinduction, Mice, Isotopes, Animal Cells, Thermal, Dosimetry, Radiations, Vertebrates 560160* -- Radionuclide Effects, Animals, X Radiation, Gene Mutations, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat, Mammals, Fluids, Progress Report, Radioisotope Generators, Electromagnetic Radiation, Biological Effects, 63 Radiation, Dose Rates, Elements, Document Types, Rare Gases, Radiation Effects, Kinetics, Nonmetals, Radon, Man, & Toxicology, Biological Radiation Effects, Gases, Mutations, Ionizing Radiations
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