
doi: 10.2172/10160253
This report describes three studies aimed at using radiolabeled pharmaceuticals to explore brain function and anatomy. The first section describes the chemical preparation of [F18]fluorinated benzamides (dopamine D-2 receptor tracers), [F18]fluorinated benzazepines (dopamine D-1 receptor tracers), and tissue distribution of [F18]-fluoxetine (serotonin reuptake site tracer). The second section relates pharmacological and behavioral studies of amphetamines. The third section reports on progress made with processing of brain images from CT, MRI and PET/SPECT with regards to brain metabolism of glucose during mental tasks.
400703, 551001, Dopamine, 610, 38 Radiation Chemistry, Unsealed Radionuclides In Diagnostics, Cerebellum, Receptors, Labelling, 616, Chemical Preparation, Tissue Distribution, Cerebrum, 59 Basic Biological Sciences, Cerebral Cortex, Behavior, Radiochemistry, 550101, Progress Report, Fluorine 18, Structure-Activity Relationships, Radioisotope Production, Amides, Rats, Spiperone, Man, Sympatholytics, Radiopharmaceuticals, Liquid Column Chromatography 550601, 62 Radiology And Nuclear Medicine, And Nuclear Chemistry, Tracer Techniques
400703, 551001, Dopamine, 610, 38 Radiation Chemistry, Unsealed Radionuclides In Diagnostics, Cerebellum, Receptors, Labelling, 616, Chemical Preparation, Tissue Distribution, Cerebrum, 59 Basic Biological Sciences, Cerebral Cortex, Behavior, Radiochemistry, 550101, Progress Report, Fluorine 18, Structure-Activity Relationships, Radioisotope Production, Amides, Rats, Spiperone, Man, Sympatholytics, Radiopharmaceuticals, Liquid Column Chromatography 550601, 62 Radiology And Nuclear Medicine, And Nuclear Chemistry, Tracer Techniques
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