This guide has been prepared to assist those in the natural gas and oil industry who may not be familiar with how the Federal government, particularly the U.S. Department of Energy (DOE or Department), does business with private sector companies. Basic information is provided on what DOE is trying to do, why it wants to work with the natural gas and oil industry, how it can work with companies, who to contact, and where to inquire for further information. This last item is noteworthy because it is important for users of this guide to be able to access information about subjects that may interest them. Selected other Federal agencies and their activities related to those of DOE`s Office of Fossil Energy (FE or Fossil Energy) also are included in this document as Appendix A. This guide provides an address and/or phone number for every topic covered to prevent any information impasse. If a question is not adequately answered by the guide, please do not hesitate to contact the appropriate person or office. It is hoped that the information provided in this guide will lead to a better understanding of the mission, roles, and procedures of DOE and result in more and better cooperative working relationships between the natural gas and oil industry and DOE. Such relationships will provide a significant benefit to our Nation`s economic, technological, and energy security.