Cloning and Functional Expression of the Rat Brain KIR6.2 Channel.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1996 English Publisher:Physiological Society of JapanJournal:The Japanese Journal of Physiology, volume 46, pages 491-495 (issn: 0021-521X,

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Authors: TAKANO, Makoto; ISHII, Takahiro; XIE, Lai-Hua;

doi: 10.2170/jjphysiol.46.491

pmid: 9087860

Cloning and Functional Expression of the Rat Brain KIR6.2 Channel.

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Abstract

We obtained cDNA encoding KIR6.2 channel from the rat brain cDNA library. The reconstituted K+ channel with KIR6.2 and SUR1 genes retained properties similar to those reported in the native ATP-sensitive K+ channel including run-down and recovery of channel activity. When KIR6.2 was co-expressed with CFTR or MDR1, no K+ channel activity was recorded.

Related Organizations

Kyoto University
Japan

Keywords

DNA, Complementary, Potassium Channels, Molecular Sequence Data, cloning, Brain, Cystic Fibrosis Transmembrane Conductance Regulator, Gene Expression, Transfection, Recombinant Proteins, Rats, ATP-sensitive K<sup>+</sup> channel, COS Cells, Animals, Amino Acid Sequence, Cloning, Molecular, Potassium Channels, Inwardly Rectifying, ABC superfamily

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