Modulation of Phagocytosis by P2-Purinergic Receptors in Mouse Peritoneal Macrophages.
Copyright policy )Modulation of Phagocytosis by P2-Purinergic Receptors in Mouse Peritoneal Macrophages.
The effects of adenosine 5'-triphosphate (ATP) and other nucleotides on phagocytosis of peritoneal macrophages were examined by means of flow cytometry (FCM). ATP and uridine 5'-triphosphate (UTP) enhanced phagocytosis in a dose-dependent manner. Control phagocytosis was partially suppressed in Ca(2+)-free solution. Phagocytosis was suppressed by ATP in Ca(2+)-free solution but not by UTP. Agonist potency order revealed that ATP enhanced phagocytosis through P2u receptors in normal external solution (NES) and inhibited it through P2z receptors in Ca(2+)-free solution. The present study showed that ATP modulates the phagocytosis of macrophages, and that two types of receptors were identified by pharmacological experiments.
- Shimane University Japan
Male, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Macrophages, Receptors, Purinergic, Uridine Triphosphate, Flow Cytometry, Mice, Adenosine Triphosphate, Phagocytosis, Animals, Female
Male, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Macrophages, Receptors, Purinergic, Uridine Triphosphate, Flow Cytometry, Mice, Adenosine Triphosphate, Phagocytosis, Animals, Female
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