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Nihon Naika Gakkai Zasshi
Article . 1987 . Peer-reviewed
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Nihon Naika Gakkai Zasshi
Article
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Nihon Naika Gakkai Zasshi
Article . 1988
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https://dx.doi.org/10.2169/nai...
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Siblings with mixed connective tissue disease.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1987 English Publisher:Japanese Society of Internal MedicineJournal:Nihon Naika Gakkai Zasshi, volume 76, pages 1,573-1,577 (issn: 0021-5384, eissn: 1883-2083, Copyright policy )
Authors: T, Fukui; H, Kondou; S, Kashiwazaki;

doi: 10.2169/naika.76.1573

pmid: 3437188

Siblings with mixed connective tissue disease.

Abstract

膠原病での家族内発症の報告は散見されるが,混合性結合組織病(mixed connective tissue disease, MCTD)での家族内発症は極めてまれである.我々は, MCTDを発症した姉妹例を経験した.妹は,レイノー現象,手指硬化症,多関節炎,拘束性換気障害,白血球減少,血小板減少, CK値上昇,抗RNP抗体陽性であった.姉は,レイノー現象,手指硬化症,肺線維症,筋力低下,白血球減少,血小板減少, CK値上昇,抗RNP抗体陽性であった.姉妹ともに厚生省MCTD研究班の診断の手引きに合致しており, MCTDと診断し得た.姉妹のHLA抗原の分析では,共通してAw24, B7, Cw7, DR1抗原を有していた.かかる症例は,本症の発症に遺伝学的背景因子が存在する可能性を示唆するものと考えられた.

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Keywords

Adult, HLA Antigens, Humans, Female, Raynaud Disease, Mixed Connective Tissue Disease

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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