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Nihon Naika Gakkai Zasshi
Article . 1987 . Peer-reviewed
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Impaired intermediate-density lipoprotein triglyceride hydrolysis in familial lecithin : cholesterol acyltransferase (LCAT) deficiency.

Authors: S, Murano; K, Shirai; Y, Saito; S, Yoshida; Y, Ohta; S, Yamamoto; H, Tsuchida;

Impaired intermediate-density lipoprotein triglyceride hydrolysis in familial lecithin : cholesterol acyltransferase (LCAT) deficiency.

Abstract

本邦第5家系目の家族性レシチンコレステロールアシルトランスフェラーゼ欠損症患者の血中には,中間リポ蛋白(IDL)が存在していた, IDLを放射性トリオレイン(14C-triolein)でラベルし,これを基質として肝性リパーゼを作用させた時,正常人の食後血清から得たIDLを同様な方法で調製した基質に比較して,中性脂肪の水解の低下がみられた.この反応系に正常人血清を添加した時,水解の亢進がみられたが,同時に5, 5′-Dithiobis-(2-nitrobenzoic acid) (DTNB)を加えた時には水解の亢進はみられなかつた.以上のことより本症例におけるIDLの出現は, LCAT欠損によるIDL粒子の構成成分の変化,特にフリーコレステロールの増加がその-因となつていることが推測された.

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Keywords

Adult, Lecithin Cholesterol Acyltransferase Deficiency, Lipoproteins, IDL, Hydrolysis, Lipoproteins, Homozygote, Humans, Female, Hypolipoproteinemias

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Average
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