The Gaza Strip suffers severe constraints in water supply due to its location, confinement, high population density and semi-arid coastal climate. To improve water and agricultural resources, a study was undertaken to show the requirements in planning and management for wastewater treatment, irrigation conveyance and aquifer recharge to meet high technical standards and sustainable economic benefits. Particular attention is paid to economic, financial and socioeconomic analysis. This paper discusses the impact that wastewater reuse will have on the water resources as part of the overall water balance in the Gaza Strip.