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Drugs in R&D
Article . 2010 . Peer-reviewed
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Drugs in R&D
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Drugs in R&D
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Abiraterone Acetate

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Nov 2010 English Publisher:Springer Science and Business Media LLCJournal:Drugs in R&D, volume 10, pages 261-269 (issn: 1174-5886, eissn: 1179-6901, Copyright policy )

doi: 10.2165/11587960-000000000-00000

pmid: 21171672

pmc: PMC3586139

Abiraterone Acetate

Abstract

Abiraterone acetate (CB 7630; CB7630; JNJ-212082), the 3β-acetate prodrug of abiraterone, is structurally related to ketoconazole and is being developed by Cougar Biotechnology as a hormonal therapy for advanced prostate and breast cancers. As a selective inhibitor of adrenal androgens, it is thought to be a safer product than existing second-line hormonal therapies. This review discusses the key development milestones and therapeutic trials of this drug.

Keywords

Pharmacology, Antineoplastic Agents, Hormonal, Abiraterone Acetate, Drug Evaluation, Preclinical, Androgen Antagonists, Drugs, Investigational, Adis R&D Profile, Androstadienes, Neoplasms, Animals, Humans, Prodrugs

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
Green
gold
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