The natural part of podoplanin is still inadequately comprehended. With respect to critical part of cell–cell connections in supportive of incendiary cytokine creation, a component stayed to be recognized. The aim of the present study was to evaluate serum level of Podoplanin in patients with vitiligo and assessment of its clinical significance. and its role in pathogenesis of vitiligo. The study was conducted on fifty vitiligo patients and thirty age and sex matched healthy volunteers served as controls. All participants were tested for determination of Podoplanin level Higher PDPN was significantly associated with vitiligo patients. PDPN best cut of value for discrimination between cases and controls. Higher PDPN was considered as risk predictor for vitiligo occurrence, as well as for more severe cases.