Eudragit polymeric films were investigated as a potential drug delivery system forcontrolling the release of tetracaine HCl. The effect of modification in polymeric ratio of bothEudragit RS100 and RL100, drug loading and nature of plasticizer on the in vitro release of thedrug from each film into a receiving medium of citrate buffer (pH=5) was measured. Theobtained results indicated that the film containing Eudragit polymer and plasticizer affected thedrug release rate and that the release followed Higuchi-diffusion model. The release rate wasfound to be enhanced with increasing Eudragit RL100 ratio. The release rate was also found tobe directly proportional to drug concentration. Tetracaine HCl was slowly released fromEudragit RS100 / dimethylphthalate films and Eudragit RS100 / diethyl-phthalate films.Eduragit films plasticized with GTA, PEG400 and PG produced a fast drug release. This studydemonstrated that tetracaine HCl was compatible with Eudragit RS100 as indicated by theclear and transparent formed films. Also, the characterizations of Eudragit films wereconducted by IR-spectroscopy, X-ray diffraction pattern and differential thermal analysis toexplore the possibility of the drug polymer interaction occurring between tetracaine HCl andeither Eudragit RS100 or Eudragit RL100. The therapeutic potential of tetracaine HCl Eudragitpolymeric films was evaluated using "Tail-Flick" method on a Techano analyiseometer model.Results indicated that tetracaine HCL polymeric film composed of Eudragit RS100: EudragitRL100 ratio (8:2) and plasticized with 20% w/w diethylphthalate gave a long duration ofanalgesic response.