A phytochemical study of Euphorbia heterophylla L. cultivated in Egypt is presented. b-amyrin, b-sitosterol taraxasterol acetate, b-sitosterol glucoside and hydrocarbon with ketonic group were isolated from pet. ether extract of the herb. While lupeol acetate, teraxasterol, b-sitosterol and b-sitosterol glucoside were isolated from ether extract of the root. In addition quercetin 3-methyl quercetin, kaempferol-3-0-arabinoside. kaempferol-3-0-glucoside and kaempferol-7-0-glucoside sere isolated from the ethyl acetate extract of the herb. The identification of these compounds was based on physical, chemical and spectral analysis.