Proteolytic activation of the epithelial sodium channel (ENaC) in health and disease
Copyright policy )Proteolytic activation of the epithelial sodium channel (ENaC) in health and disease
ber of the ENaC/degenerin family of non-voltage gated ion channels. ENaC is localized in the apical membrane of epithelial cells, and is the rate limiting step for sodium absorption in a number of epithelial tissues like the aldosterone-sensitive distal nephron (ASDN), respiratory epithelia, distal colon, sweat and salivary ducts. ENaC is probably a heterotrimer with three well characterized subunits (αβγ). In humans an additional δ-subunit (δ-hENaC) exists but little is known about its function.
- University of Erlangen-Nuremberg Germany
Cystic Fibrosis, Pseudohypoaldosteronism, Liddle’s syndrome, Respiratory Tract Diseases, sodium transport, epithelial sodium channel (ENaC), Disease Models, Animal, Mutation, Animals, Humans, Kidney Diseases, Epithelial Sodium Channels, pseudohypoaldosteronism type I (PHA1), cystic fibrosis (CF), Peptide Hydrolases
Cystic Fibrosis, Pseudohypoaldosteronism, Liddle’s syndrome, Respiratory Tract Diseases, sodium transport, epithelial sodium channel (ENaC), Disease Models, Animal, Mutation, Animals, Humans, Kidney Diseases, Epithelial Sodium Channels, pseudohypoaldosteronism type I (PHA1), cystic fibrosis (CF), Peptide Hydrolases
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