Objectives:Osteocalcin, an osteoblast-specific protein, has recently been reported to affect energy metabolism, this study aimed to assess the relationship between serum total osteocalcin and measurements of adiposity and lipid profile in type II diabetic Sudanese patients. Methods: In this cross-sectional study, 115 people with type II diabetes (34 men, 81 women) aged 18 to 94 years were enrolled in the study. Total osteocalcin and insulin were measured using ELISA (enzyme-linked immunosorbent assay) technique. Fasting blood glucose and lipid profile were measured by a spectrophotometer. Results: Mean serum osteocalcin concentration in diabetic patients was significantly lower than those in control subjects (p ≤ 0.001). When the test was done between TOC and lipid profile, there was a moderate negative correlation between TOC and TCHOL. Which was statistically significant (P = 0.003). There was a moderate negative correlation between TOC and TG. Which was statistically non-significant (P = 0.057). There was a strong positive correlation between TOC and HDL. Which was statistically significant (P = 0.000). There was a weak positive correlation between TOC and LDL. That is statistically non-significant P = 0.105. Conclusion:Our findings showed a statistically highly significant negative correlation between TOC and fasting blood glucose concentration. Similarly, the correlation between FBG and ucOC, age, BMI, TCHOL, and HDL showed a negative correlation that was not significant.