Hypopituitarism is defined as deficiency of one or more hormones of the pituitary gland which can result from diseases of the pituitary gland or from diseases of the hypothalamus causing diminished secretion of hypothalamic releasing hormones, thereby reducing secretion of the corresponding pituitary hormones.Clinical manifestations depend on the extent of hormone deficiency and may be non-specific, such as fatigue, hypotension, cold intolerance, or more indicative such as growth retardation or impotence and infertility in GH and gonadotropin deficiency.