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Risk Management and Healthcare Policy
Article . 2025 . Peer-reviewed
License: CC BY NC
Data sources: Crossref
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PubMed Central
Article . 2025
License: CC BY NC
Data sources: PubMed Central
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Dove Medical Press
Article . 2025 . Peer-reviewed
Data sources: Dove Medical Press
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Daily Improvement in APACHE II Score (APACHE/m) and Outcomes in ICU Trauma Patients

Authors: Pao-Jen Kuo; Sheng-En Chou; Hang-Tsung Liu; Ching-Hua Tsai; Ching-Hua Hsieh;

Daily Improvement in APACHE II Score (APACHE/m) and Outcomes in ICU Trauma Patients

Abstract

The Acute Physiology and Chronic Health Evaluation II (APACHE II) is a widely used intensive care unit (ICU) severity score; however, it provides only an admission snapshot. Therefore, we introduced a novel metric, APACHE/m (average daily decrease in APACHE II score during ICU stay), to examine whether faster physiological improvement was correlated with better outcomes in ICU trauma patients.This retrospective cohort study was conducted at a level I trauma center. Participants comprised 1784 adult trauma patients admitted to the ICU (2016-2023) who survived ICU discharge were included in this study. The APACHE II scores at ICU admission and discharge were recorded. APACHE/m was calculated as the decrease in APACHE II divided by the length of stay in the ICU. We analyzed the ability of APACHE/m to predict post-ICU in-hospital mortality and compared outcomes between the high and low APACHE/m groups. Propensity score matching (1:1) was used to adjust for initial injury severity and comorbidities.Hospital mortality after ICU discharge was 2.3% (41/1784). APACHE/m alone showed poor discrimination for mortality (AUC = 0.57). In the unmatched cohort, mortality was 2.6% in high APACHE/m patients (>1.03 points/day) vs 2.0% in low APACHE/m patients (≤1.03), P = 0.523. After matching (199 pairs), high APACHE/m patients had longer hospital stays (median, 14 vs 12 days, P = 0.005) and higher mortality (3.5% vs 0%, P = 0.022) than matched low APACHE/m patients.A rapid APACHE II score decline (high APACHE/m) did not predict improved survival in ICU trauma patients. Paradoxically, the patients with the fastest APACHE II improvements had similar or worse late outcomes, likely because they were initially more critically ill. Thus, initial severity remains an important predictor of outcomes than the ICU recovery rate.

Keywords

Risk Management and Healthcare Policy, Original Research

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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gold