ORIENT-31 as the Sakigake “Charging Samurai” Born of IMpower150 but Will MARIPOSA-2 IMPRESS in the “Meiji Modernization” of Post-3G EGFR TKI Progression?
Copyright policy )ORIENT-31 as the Sakigake “Charging Samurai” Born of IMpower150 but Will MARIPOSA-2 IMPRESS in the “Meiji Modernization” of Post-3G EGFR TKI Progression?
Tyrosine kinase inhibitors (TKIs) have become the preferred first line therapy for those patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Given superior progression free survival (PFS) and overall survival (OS) when compared to earlier generations, third generation EGFR TKIs have become the first choice therapy in many parts of the world. Even though multiple strategies are in development to target both "on-target" and "off-target" resistance, the continuation of EGFR TKIs at the time of progression remains a controversial topic. This commentary focuses on both the "classic" clinical trials of IMpower150 and IMPRESS and compares them to the recently reported ORIENT-31 and ongoing MARIPOSA-2 to discuss the future therapeutic strategies in the setting of progression post-third generation EGFR TKIs.
- University of California United States
- St. Marianna University School of Medicine Japan
- UC Irvine Chao Family Comprehensive Cancer Center United States
- California Digital Library United States
- University of California, Irvine United States
EGFR+ NSCLC, sintilimab, ORIENT-31, 616, Commentary, 610, EGFR TKI, bevacizumab biosimilar, T790M, third-generation EGFR TKI
EGFR+ NSCLC, sintilimab, ORIENT-31, 616, Commentary, 610, EGFR TKI, bevacizumab biosimilar, T790M, third-generation EGFR TKI
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).4 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!