
Following the successful development of long-acting steroid-releasing vaginal ring devices for the treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlled-release technology, before describing the various types of ring device available today. The remainder of the article highlights the key developments in HIV microbicide-releasing vaginal rings, with a particular focus on the dapivirine ring that is presently in late-stage clinical testing.
dapivirine, /dk/atira/pure/subjectarea/asjc/2700/2730; name=Oncology, antiretroviral, 610, Review, /dk/atira/pure/subjectarea/asjc/2700/2729, SILCS diaphragm, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being, sustained release, thermoplastic, /dk/atira/pure/subjectarea/asjc/2900/2913; name=Maternity and Midwifery, name=Obstetrics and Gynaecology, name=Oncology, Gynecology and obstetrics, name=Maternity and Midwifery, name=SDG 3 - Good Health and Well-being, /dk/atira/pure/subjectarea/asjc/2700/2729; name=Obstetrics and Gynaecology, /dk/atira/pure/subjectarea/asjc/2700/2730, /dk/atira/pure/subjectarea/asjc/2900/2913, RG1-991, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, controlled release, silicone elastomer
dapivirine, /dk/atira/pure/subjectarea/asjc/2700/2730; name=Oncology, antiretroviral, 610, Review, /dk/atira/pure/subjectarea/asjc/2700/2729, SILCS diaphragm, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being, sustained release, thermoplastic, /dk/atira/pure/subjectarea/asjc/2900/2913; name=Maternity and Midwifery, name=Obstetrics and Gynaecology, name=Oncology, Gynecology and obstetrics, name=Maternity and Midwifery, name=SDG 3 - Good Health and Well-being, /dk/atira/pure/subjectarea/asjc/2700/2729; name=Obstetrics and Gynaecology, /dk/atira/pure/subjectarea/asjc/2700/2730, /dk/atira/pure/subjectarea/asjc/2900/2913, RG1-991, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, controlled release, silicone elastomer
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 79 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 1% |
