
The evolution of knowledge concerning COPD and its components--emphysema, chronic bronchitis, and asthmatic bronchitis--covers 200 years. The stethoscope and spirometer became important early tools in diagnosis and assessment. Spirometry remains the most effective means of identification and assessment of the course of COPD and responses to therapy, and is grossly underused for this purpose. Knowledge of the pathogenesis, course and prognosis, and new approaches to therapy have dramatically improved our understanding of this important clinical entity. Smoking cessation improves the early course of disease. Long-term oxygen improves the length and quality of life in selected patients with hypoxemia. Surgery benefits a select few. Today, COPD is a steadily growing global healthcare problem, with increasing morbidity and mortality. Early identification and prevention, and treatment of emerging stages of disease through smoking cessation and a growing number of bronchoactive drugs promises to change the outcome.
Adult, Male, Adolescent, Guinea Pigs, Oxygen Inhalation Therapy, History, 19th Century, Congresses as Topic, History, 20th Century, History, 18th Century, History, 17th Century, Disease Models, Animal, Pulmonary Disease, Chronic Obstructive, Dogs, Pulmonary Emphysema, Acute Disease, Animals, Humans, Female, Lung Transplantation, Randomized Controlled Trials as Topic
Adult, Male, Adolescent, Guinea Pigs, Oxygen Inhalation Therapy, History, 19th Century, Congresses as Topic, History, 20th Century, History, 18th Century, History, 17th Century, Disease Models, Animal, Pulmonary Disease, Chronic Obstructive, Dogs, Pulmonary Emphysema, Acute Disease, Animals, Humans, Female, Lung Transplantation, Randomized Controlled Trials as Topic
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 76 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
