Emerging perspectives on laminopathies

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Apr 2016 Italy English Publisher:Informa UK LimitedJournal:Cell Health and Cytoskeleton (eissn: 1179-1330,

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Authors: Lattanzi, Giovanna; Benedetti, Sara; D’Apice, Maria Rosaria; Maggi, Lorenzo; Carboni, Nicola; Scarano, Emanuela; POLITANO, Luisa;

doi: 10.2147/chc.s59507

handle: 11591/368571

Emerging perspectives on laminopathies

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Abstract

Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.

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Italy

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Keywords

Emerin; Emery–Dreifuss muscular dystrophy; Hutchinson–Gilford progeria; Lamin A/C; Laminopathies; Cell Biology; Structural Biology; Histology; Biochemistry

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