Biological differences between Asians and Caucasians contribute to variations in the prevalence of skin disorders such as melanocytoses and skin aging. The current regenerative medicine indications were primarily developed for Caucasians; adapting them to the specific needs of Asian individuals may be beneficial. Five distinguished Asian experts had this purpose in mind when they convened to develop evidence-based and experience-based recommendations on maximizing the benefits of natural-origin ingredient Polynucleotides High Purification Technology (PN HPT™) in individuals of Asian descent. They based their recommendations on available literature and the outcomes of a digital survey. PN HPT supports dermal fibroblasts in producing collagen, elastin, and matrix by replenishing the dermal pool of nucleotide precursors.One hundred and one East Asian specialists in aesthetic and regenerative medicine accepted an invitation from Mastelli S.r.l. Sanremo, Italy, and Ardence Aesthetic, Petaling Jaya, Selangor, Malaysia (corporate sponsors), to respond to a 50-item online survey questionnaire. A subsequent consensus-building board meeting elaborated on the survey outcomes with a simplified Delphi approach, providing recommendations for the safe and effective use of PN HPT in Asian individuals.The paper highlights in specific chapters the perceptions of the surveyed East Asian specialists regarding the PN HPT indications and procedures (choice of PN HPT formulations, injection technique, scheduling, and layer) in facial areas and the neck. Furthermore, the paper discusses the experts' views on combining PN HPT with other skin regenerative strategies, as well as the innovative concept of "PN HPT Priming".Offering tailored PN HPT treatment algorithms that take into consideration the Asian biological and cultural specificities, although without stratification for age and skin quality determinants, the board's suggestions are of immediate clinical applicability and may support clinicians who use PN HPT devices in their daily regenerative medicine practice.