
doi: 10.2144/dec02fang
pmid: 12514931
Membrane-bound proteins represent the single most important class of drug targets. This article discusses the issues surrounding fabrication of membrane-protein microarrays by conventional robotic pin printing techniques. Ligand binding selectivity and specificity to G protein-coupled receptor (GPCR) microarrays are presented. The potential applications of these arrays for drug screening are discussed.
QH301-705.5, Receptors, Dopamine D1, Protein Array Analysis, Membrane Proteins, Proteins, Membranes, Artificial, Receptors, Cell Surface, Equipment Design, Ligands, Equipment Failure Analysis, GTP-Binding Proteins, Feasibility Studies, Humans, Receptors, Neurotensin, Biology (General), Receptors, Adrenergic, beta-1
QH301-705.5, Receptors, Dopamine D1, Protein Array Analysis, Membrane Proteins, Proteins, Membranes, Artificial, Receptors, Cell Surface, Equipment Design, Ligands, Equipment Failure Analysis, GTP-Binding Proteins, Feasibility Studies, Humans, Receptors, Neurotensin, Biology (General), Receptors, Adrenergic, beta-1
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