Assessment of the feto-placental unit is needed during maternal states of health and disease. This presentation will discuss practical approaches to assess reproductive efficiency and placental health. Biomarkers including pregnancy-associated glycoproteins, and the use of ultrasonography will be described. Current literature review will be presented describing the utilization of different markers to assess placental health during times of disease or determine fetal outcome following conception. The practitioner will be exposed to cutting-edge research in the area of placental health, yet walk away with a practical understanding where these progressive techniques can be used in practice.