There are three primary alterations in the body as a whole due to diarrhea: 1. Dehydration, 2. Acidosis, and 3. Electrolyte losses and imbalances. The initiating factors in the development and the magnitude of each in the acutely diarrheic neonatal calf have been discussed in Part I. This paper will briefly cover the effect that these alterations have on the body as a whole and their treatment. Only by knowing, understanding and taking into consideration these alterations and their effects on the diarrheic calf is a rational medical treatment possible.