Increasing interactions with large mammals ask for new ways of managing human-wildlife coexistence. It requires a transformation in the relationships between humans and wildlife as well as between organisations and stakeholders involved in wildlife management. Here, we draw on transformation thinking, specifically the leverage point framework, to identify opportunities for managing human-wildlife interactions for coexistence. Using the Dutch wildlife management system as a case study, we draw attention to the interactions between system levels and the importance of the deeper levels related to values, worldviews and governance design in building new ways of relating to wildlife. Overall, this study identifies four key areas, where changes would help us manage for coexistence: 1) prioritizing a holistic or system approach; 2) taking an adaptive approach to understanding human-wildlife interactions; 3) building collaboration and trust to ensure mutual learning; and 4) having an overarching vision on how to live together with wildlife.