Dermatophyte infection is commonly treated in dermatology and primary care offices. Historically, certain dermatophyte species have been ubiquitous globally, while others have been localized to specific geographic and socioeconomic regions. However, with increased globalization and international travel, there has been a shift in the geographic confines of certain species as well as a rise in antifungal-resistant dermatophyte infections—including drug-resistant Trichophyton indotineae (T. indotineae). We present a case of T. indotineae infection in a male that was successfully treated with oral itraconazole. This emerging pathogen most commonly affects immunocompetent hosts and travelers from Southeast Asia. Frontline clinicians should maintain a high index of suspicion for T. indotineae in patients with widespread, treatment-refractory dermatophytosis and a consistent epidemiologic history.