This study presents a new concept, referred to as Critical Energy Density (CED), for estimating the Minimum Ignition Energy (MIE) of organic powders. Only readily experimental data, such as granulometric analysis, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC), are required for running the mathematical model. The algorithm simulates the heating of a dust cloud exposed to an electrical spark and detects the ignition by comparing the energy released by the volatiles’ homogeneous combustion with a threshold value corresponding to the minimum energy required to sustain the flame propagation (that is, the CED). Validation was performed on six different organic powders, with estimated MIE values showing good agreement with experimental data. This approach provides a cost-effective tool for early-stage hazard assessment in industrial environments where combustible powders are present and supports the development of a safer process design.