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Journal of Theoretical Biology
Article . 2025 . Peer-reviewed
License: CC BY
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zbMATH Open
Article . 2025
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https://doi.org/10.2139/ssrn.5...
Article . 2025 . Peer-reviewed
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Heat Delivery Accompanying Pulsed Field Ablation

Heat delivery accompanying pulsed field ablation
Authors: Angiolo Farina; Antonio Fasano; Massimo Grimaldi; Fabio Rosso;

Heat Delivery Accompanying Pulsed Field Ablation

Abstract

Pulsed Field Ablation (PFA) is a technique to achieve pulmonary vein isolation, alternative to the traditional thermal ablation procedures. Instead of delivering or subtracting heat, PFA uses rapid pulses of a high intensity electric field, inducing cells electroporation. PFA is usually claimed not to influence the temperature in the surroundings of the ablation site. Nevertheless, in some case a non-negligible increase of the patient's luminal esophageal temperature has been observed. Here we set up a mathematical model to provide a theoretical basis to the latter observation, considering a worst case scenario.

Country
Italy
Related Organizations
Keywords

Ablation Techniques, Hot Temperature, Biophysics, mathematical modeling, Pulsed Field Ablation; Atrial Fibrillation; Mathematical Modeling; Heat Diffusion, Electroporation, pulsed field ablation (PFA), Medical applications (general), Pulmonary Veins, atrial fibrillation (AF), esophageal thermal lesion (ETL), Catheter Ablation, Humans, Joule effect, heat diffusion

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    2
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Top 10%
Average
Average
Green
hybrid