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Radiotherapy and Oncology
Article . 2025 . Peer-reviewed
License: CC BY NC ND
Data sources: Crossref
https://doi.org/10.2139/ssrn.5...
Article . 2024 . Peer-reviewed
Data sources: Crossref
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On the Ptv Homogeneity Objective in the Era of Photon Advanced Dose Calculation Algorithms: Bridging Robust and Ptv-Based Planning

Authors: Diego, Jurado-Bruggeman; Agnes, Angerud; Albin, Fredriksson; Carles, Muñoz-Montplet;

On the Ptv Homogeneity Objective in the Era of Photon Advanced Dose Calculation Algorithms: Bridging Robust and Ptv-Based Planning

Abstract

The planning target volume (PTV) homogeneity objective was developed for previous-generation dose calculation algorithms. Advanced algorithms report doses to medium-in-medium (Dm,m) and their values depend on the medium considered, breaking the link between uniform irradiation and dose homogeneity. This work revises the PTV homogeneity objective when high-density heterogeneities are involved. We evaluated robust against PTV-based planning, and a dose reporting method that removes composition dependencies to express doses to muscle in muscle-like medium (Dmuscle,muscle*).Four cases featuring bone or metal within the PTV were selected and planned in RayStation with Monte Carlo. Three plans were created for each case: robust optimization for Dm,m (Robust-Dm,m), and PTV-based optimization for Dm,m (PTV-Dm,m) and Dmuscle,muscle* (PTV-Dmuscle,muscle*). The plans were reported in Dm,m and Dmuscle,muscle*, and their dosimetric parameters, robustness, complexities, and optimization times were assessed.Robust-Dm,m and PTV-Dmuscle,muscle* plans presented similar Dm,m distributions with inhomogeneous PTV doses due to cold spots in high-density regions. PTV-Dm,m plans achieved homogeneous PTV doses but required local fluence compensations that impaired robustness, with significant hot spots, and increased complexity. Robust optimization was 7 to 11 times slower. Reporting in Dmuscle,muscle* restored consistency between PTV-based and robust evaluations.Robust optimization proves that PTV homogeneity should not be prioritized when advanced algorithms reporting Dm,m are used with high-density heterogeneities. PTV-Dmuscle,muscle* optimization offers a practical alternative for maintaining PTV-based planning and the PTV homogeneity objective while ensuring consistency with robust optimization. Dmuscle,muscle* reporting simplifies plan evaluation and aligns with clinical practice, facilitating decision-making in treatment planning.

Keywords

Photons, Radiotherapy Planning, Computer-Assisted, Humans, Radiotherapy Dosage, Monte Carlo Method, Algorithms

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
hybrid