Samples of refined petroleum fuels from the three major oil-marketing companies (GOIL Company Limited, Total Energies Ghana Limited and Shell Vivo Ghana Limited) in Ghana have been analysed for elemental concentrations using an X-ray fluorescence facility at the National Nuclear Research Institute, Ghana Atomic Energy Commission. The samples were acquired from seven different fuel service stations where customers directly purchase refined petroleum fuels such as diesel, petrol and kerosene. The X-ray fluorescence method was considered for the study because sample preparation does not require the addition of reagents, and the fluorescence measurements involve a direct electron transition effect. The fluorescence study was carried out to estimate the concentrations of sulphur and other contaminants in the major refined petroleum fuel products patronised in Ghana. The average sulphur concentration in the samples of diesel products were 17.543, 25.805 and 26.813 ppm in DFS, DE and DXP samples compared to 22.258, 22.623 and 15.748 ppm in petrol samples of PE, PXP and VP. Also, the sulphur concentration of sample KE, kerosene products, is 33.250 ppm. Among the diesel samples, DE and DXP recorded the highest but most comparable average concentration of elemental contaminants, and DFS the least, while PXP recorded the least among the petrol samples. The study estimated the concentrations of four heavy metal elements that are toxic to biological life (Hg, Pb, Cr and Mn) to be less than 10.0 ppm, except Cr. The study concluded that most of the elemental contaminants of heavy metals in the samples were relatively less than ultra-low levels. Therefore, exhaust emissions may have little impact on the environment. Also, the content of the ash-producing metal elements in each sample of the seven refined fuel products is between 10.0 and 50.0 ppm. Since the concentration of sulphur and a few other elemental contaminants could not meet the internationally accepted standard (<10.0 ppm), the imported refined fuel products used in Ghana may be considered relatively good but not environmentally safe.