Diarylheptanoid Glycosides from Dioscorea Nipponica Rhizomes
Copyright policy )Diarylheptanoid Glycosides from Dioscorea Nipponica Rhizomes
A group of previously undescribed diarylheptanoids with mono/di-glucose substitution, diodiarylheptosides A-F (1-6), together with six known diarylheptanoids (7-12) were isolated from the rhizomes of Dioscorea nipponica. Their structures were established by comprehensive UV, IR, HR-ESI-MS and NMR analyses, and their absolute configurations were determined by a comparison of calculated and experimental ECD, some with optical rotations, after acid-hydrolysis. Moreover, bioassay results showed that compounds 3 and 11 exhibited stronger NO inhibitions on lipopolysaccharides-induced RAW 264.7 cells, with the IC50 values of 14.91 ± 0.62 and 12.78 ± 1.12 μM.
- Institute of Chinese Materia Medica China (People's Republic of)
- Henan University China (People's Republic of)
- China Academy of Chinese Medical Sciences China (People's Republic of)
Mice, China, RAW 264.7 Cells, Molecular Structure, Dioscorea, Diarylheptanoids, Phytochemicals, Animals, Glycosides, Nitric Oxide, Rhizome
Mice, China, RAW 264.7 Cells, Molecular Structure, Dioscorea, Diarylheptanoids, Phytochemicals, Animals, Glycosides, Nitric Oxide, Rhizome
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