Quantum genetic algorithms (QGA) integrate genetic programming and quantum computing to address search and optimization problems. The standard strategy of the hybrid QGA approach is to add quantum resources to classical genetic algorithms (GA), thus improving their efficacy (i.e., quantum optimization of a classical algorithm). However, the extent of such improvements is still unclear. Conversely, Reduced Quantum Genetic Algorithm (RQGA) is a fully quantum algorithm that reduces the GA search for the best fitness in a population of potential solutions to running Grover’s algorithm. Unfortunately, RQGA finds the best fitness value and its corresponding chromosome (i.e., the solution or one of the solutions of the problem) in exponential runtime, O(2n/2), where n is the number of qubits in the individuals’ quantum register. This article introduces a novel QGA optimization strategy, namely a classical optimization of a fully quantum algorithm, to address the RQGA complexity problem. Accordingly, we control the complexity of the RQGA algorithm by selecting a limited number of qubits in the individuals’ register and fixing the remaining ones as classical values of ‘0’ and ‘1’ with a genetic algorithm. We also improve the performance of RQGA by discarding unfit solutions and bounding the search only in the area of valid individuals. As a result, our Hybrid Quantum Algorithm with Genetic Optimization (HQAGO) solves search problems in O(2(n−k)/2) oracle queries, where k is the number of fixed classical bits in the individuals’ register.