This is an important part of our ‘globalization of science movement’ particularly for the social sciences because it allows a multi-cultural and a multi-dimensional interpretation of issues, and also allows solutions to various intractable and seemingly complex problems and issues birthed in various cultural contexts. The ideas and concepts of “Cultural frame of reference” and “Cross-cultural frame of reference” were already introduced by us in passing in our papers on the certainty uncertainty principle, cross-cultural research design, structured apperception tests, extended identity theory, ethnography of enculturation, and twenty-first century intellectualism, all of which were published in the year 2023. This issue is not a trifle or a bagatelle, and not certainly a laughing matter. It therefore deserves to be studied in all seriousness by social sciences researchers. It has several practical applications in fields such as social and cultural change and betterment, religious reform, the design of contemporary education systems, cross-cultural research design, behavioural studies, and even technological advancement and betterment. These concepts must be brought into fruition through the use of various social science research techniques such as ethnography, fieldwork, the participant observation method, interviews, questionnaires, emic studies, and the like. This paper is therefore a logical culmination of all our earlier efforts, and all the aforesaid papers besides our other papers have been linked together in a continuous chain.