Malignant cardiac neoplasms (MCN) are uncommon tumors, and there are few data-driven studies that examine the trends and characteristics of the numerous subtypes. This retrospective study aims to illuminate, summarize, and discuss trends surrounding MCN and associated co-occurrences by leveraging a larger dataset than previous studies. The HCUS-NIS database was utilized for this study and consisted of 482,872,274 weighted discharges, of which 5,610 included a diagnosis for an MCN. This diagnosis was found to be more common in males (53%), and the median age was 51.96 years old. The most common cardiovascular co-occurrences in patients with diagnosed MCN were tachyarrhythmias (19.94%). The most common co-occurring neoplasms were found to be lung (23.11%), bone (10.42%) and unspecified (7.9%). Weighted in-hospital mortality was determined to be 10.12%, and the most prevalent procedures were chemotherapy (20.65%) and cardiac surgery (15.03%). Overall, this study demonstrated a low prevalence (<0.01%) of malignant cardiac neoplasms in US hospitalizations during the 13-year study period. Our study found important data that quantified and reinforced high in-hospital mortality, large numbers of procedures, and high cost incurred by patients with this rare diagnosis.