Background: The genus Schistosoma infects snails such as Bulinus spp., Oncomelania spp., and Biomphalaria spp. Host-parasite interaction of schistosomiasis includes induction of T helper type 1 (Th2) and reactive oxygen species (ROS). Objectives: This study, the author describes about intermediate host and host-parasite interaction in schistosomiasis as objectives of this study. Methodology: The author searched the information on the internet for articles on S. japonicum schistosomiasis. Articles were unrestricted open access, permissions from Elsevier, in English, and relevant publications were also included. Results: Intermediate host of S. haematobium consists of such as B. camerunsis, B. forskalii, B. globusus, and B. tropica. Intermediate host of S. japonicum consists of such as O. hupensis chiui, O. hupensis hupensis, O. hupensis linduensis, and O. hupensis quadrasi. Intermediate host of S. mansoni consists of such as B. alexandrina, B. angulosa, B. choanomphala, and B. glabrata. There are other Schistosoma spp. that can infect humans. These include such as S. intercalatum, S. malayensis, and S. mekongi. Intermediate host of S. intercalatum is B. forskalii. Intermediate host of S. malayensis is Robertsiella karporensis. Intermediate host of S. mekongi is Neotricula aperta. For the host-parasite interaction, it may include response of the host to parasite substances, induction of T helper type 2 (Th2) responses to parasite eggs. Exposure of the host to life cycle stage elicits a polarized Th2 response to antigens. Schistosoma infection result in granuloma formation as a protective mechanism. However, it is also responsible for the disease development. Reactive oxygen species (ROS) from the snail is in attempt to stop the parasite’s development. Conclusions: Intermediate hosts of the genus Schistosoma include such as Bulinus spp. Oncomelania spp., and Biomphalaria spp. Host-parasite interaction can include such as induction of Th2 and ROS and granulomas formation and the development of the disease.