The study investigated the effect of supply chain integration on the performance of supply chains. Specifically, the study investigated the effect of information, operational and relational integration of supply chains and how they affect the overall performance of the supply chain. The study administered 1500 questionnaires to some selected supply chain and information systems specialists and based on the responses received, 400 questionnaires were fully completed and which was used in the analysis of the study. Based on the findings, it was found that information and operation integration had a positive effect on supply chain performance whiles relational integration has a negative effect on supply chain performance. The result implies that within the Ghanaian context managers should invest more in information and operation integration in order to achieve positive outcomes in their supply chain whiles relationship integration should be done with more caution because of its underlying elements of trust and long-term commitments.