This paper provides comparative analysis of policy aims and possible effects of oil revenue management in Ghana. The proposals in selected sections of the Petroleum Revenue Management Bill of 2010 provide the basis for the paper. Collateralisation of oil revenue allows the country to use future revenue from oil as security. This has been used in countries such as Italy, Mexico, Brazil, and Argentina among others for various economic reasons. It is clear the motivation for Ghana to collateralised future oil revenue is not the same as that of Argentina and Mexico hence any attempt to discuss the issue must be done in context. Ghana’s case is not to prevent currency or financial market crisis but to revolutionalise investment in development infrastructure. The Petroleum Revenue Management Bill when finally promulgated into law will help mitigate the reservation against collateralisation. Prudent management and effective governance and accountability structures may fortify the current policy desire to accelerate social and economic infrastructural development. In addition, an effective natural resource management should focus on mitigating the possibility of The Dutch Disease. Exports from previously competitive sectors such as agriculture must not be sacrificed.