Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2003 English Publisher:Japanese Society for the Study of XenobioticsJournal:Drug Metabolism and Pharmacokinetics, volume 18, pages 218-221 (issn: 1347-4367,

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Authors: SAITO, Tetsuya; EGASHIRA, Mari; KIYOTANI, Kazuma; FUJIEDA, Masaki; YAMAZAKI, Hiroshi; KIYOHARA, Chikako; KUNITOH, Hideo; +1 Authors

doi: 10.2133/dmpk.18.218

pmid: 15618738

Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese

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Abstract

We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile(448)Asn, Arg(464)Cys, and Arg(477)Trp and Pro(492)Arg, respectively) were as follows:SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-GTCAACCCATCT-/TGAGTTCCTACCT-3'.SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-GTGAGAAGGTGAT/ATATCTTTGGCAT-3'.SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'.SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-ATCCTGCTGCAAC/TGGGTGGAATTCA-3'.SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-TGGACATGACCCC/GCATCTATGGGCT-3'.

Related Organizations

Hokkaido University
Japan
National Cancer Center Hospital
Korea (Republic of)
Hokkaido Bunkyo University
Japan
National Cancer Center Hospital East
Japan
Kyushu University
Japan

Keywords

genetic polymorphism, aryl hydrocarbon hydroxylase, P450 1A1

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