A Major Genotype in UDP-glucuronosyltransferase 2B15
Copyright policy )A Major Genotype in UDP-glucuronosyltransferase 2B15
A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'. This SNP was expected to cause a change of an amino acid residue at the position 523 (Thr to Lys) located in a putative co-factor binding region. The allele frequency of this SNP was 79% in Japanese, suggesting this polymorphism to be a major genotype in Japanese people.
- Hokkaido University Japan
- Hokkaido Bunkyo University Japan
novel SNP, co-factor binding region, and <i>cis</i>-4-hydroxytamoxifen glucuronidase, SSCP
novel SNP, co-factor binding region, and <i>cis</i>-4-hydroxytamoxifen glucuronidase, SSCP
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