Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae
Copyright policy )Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae
To elucidate the mechanisms underlying adriamycin resistance, adriamycin resistance-related genes were explored using the budding yeast Saccharomyces cerevisiae as a useful eukaryotic model. The CLN1 and CLN2 genes, encoding G1 cyclin, and the ERG13 gene, encoding 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, were identified.
- Tohoku University Japan
Hydroxymethylglutaryl-CoA Synthase, Antibiotics, Antineoplastic, Saccharomyces cerevisiae Proteins, Resistance, G1 cyclin, Saccharomyces cerevisiae, Yeast, Adriamycin, Doxorubicin, Drug Resistance, Neoplasm, HMG-CoA synthase, Cyclins, Gene Expression Regulation, Fungal
Hydroxymethylglutaryl-CoA Synthase, Antibiotics, Antineoplastic, Saccharomyces cerevisiae Proteins, Resistance, G1 cyclin, Saccharomyces cerevisiae, Yeast, Adriamycin, Doxorubicin, Drug Resistance, Neoplasm, HMG-CoA synthase, Cyclins, Gene Expression Regulation, Fungal
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